Well, this will certainly upset the pro-vax community.

I have included some key points, but not nearly all the pertinent information and facts. Please see the included link for more information.

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North American Journal of Medical Sciences – Regressive Autism:

📍https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364648/

What is regressive autism and why does it occur? Is it the consequence of multi-systemic dysfunction affecting the elimination of heavy metals and the ability to regulate neural temperature?

📍Abstract:

There is a compelling argument that the occurrence of regressive autism is attributable to genetic and chromosomal abnormalities, arising from the overuse of vaccines, which subsequently affects the stability and function of the autonomic nervous system and physiological systems. That sense perception is linked to the autonomic nervous system and the function of the physiological systems enables us to examine the significance of autistic symptoms from a systemic perspective. Failure of the excretory system influences elimination of heavy metals and facilitates their accumulation and subsequent manifestation as neurotoxins: the long-term consequences of which would lead to neurodegeneration, cognitive and developmental problems. It may also influence regulation of neural hyperthermia. This article explores the issues and concludes that sensory dysfunction and systemic failure, manifested as autism, is the inevitable consequence arising from subtle DNA alteration and consequently from the overuse of vaccines…

📍Introduction:

That the occurrence of autism has risen steadily in the last decades is not in dispute. Prior to the 1930’s and the introduction of vaccinations autism was unknown. By 1968 in the UK, when Polio and DPT vaccines were given at 6 and 7 months autism was very rare. In 1988, when Polio and DPT was given at 3 months, DPT at 5 months and MMR at c13 months autism rates were still low. In 1996, when Polio and DPT/HIB injections were given at 2, 3 and 4 months, followed by MMR at c13 months autism rates began rising rapidly. By 2006 the occurrence of autism had reached pandemic proportions. In the period shortly before the 1980’s the occurrence of autism was estimated to be circa 3-5 per 10,000; the majority having autism from birth[1]. Since the introduction of multiple vaccines the prevalence of autism has increased to an estimated 1 in 166 i.e. 60 per 10,000. Furthermore the trend is that of a continued increase. Some British teachers are claiming to see ASD in one in every 86 children[2]. This is supported by research which suggests that one in 100 British children may have some form of autism[3] and that ASDs are more prevalent than hitherto imagined[4] i.e. only severe cases of autism are recorded in the statistics. Such claims have been dismissed as mere speculation on the basis that there is not yet definitive proof of such claims however the perceived lack of evidence does not indicate that proof does not exist[5,6]. It may indicate that the understanding of the condition remains ‘beyond the prevailing level of knowledge’ (Table 1) [7].

By 1985 the incidence of regressive autism had equalled that from birth. By 1997 both types had increased although the regressive form was now >75% of the total occurrence. This suggests that an acquired condition was overtaking birth defects or purely genetic conditions. Autism affects four boys to every girl[10]. By contrast Autism appears not to occur in communities which do not use vaccines[11]. It occurs in immigrants from tropical climates who appear to have greater familial predisposition to autism[12] e.g. among Somali students in Minneapolis there was a rate of 1 in 28 (which compares with the local average of 1 in 56). This is more than five times the national rate of 1 in 150. Since the 1960’s the number of vaccines given to a child before entering school has risen to c33. In children born to military families the occurrence of autism may now be as low as 1 in 67. In the vast majority of cases, the emergence of autistic indications appears to happen in children who had developed normally[10,13,14], and before three years[15,16]. The development of normal immune function appears to cease in the second year and is linked to the schedule of vaccines[17] and/or the MMR vaccine[18,19]. The consequences to society are estimated at c£2.4M in an autistic child’s lifetime[20] which, if it continues to increase as many predict, will impose an unsustainable financial burden upon healthcare, education and social welfare systems…

📍The Effect of Heavy Metals:

Heavy Metals and Mercury in particular, affects the function of the CNS and are extensively documented and associated with autism[229]. Amongst a variety of side-effects mercury decreases lymphocyte viability, and in the brain: dysfunction in the amygdala, hippocampus, basal ganglia, and cerebral cortex; destruction of neurons in the cerebellum; and brainstem abnormalities. Demyelination is evident in such conditions. The brain’s electrical patterns are similarly abnormal.

The most significant contributors to the increased mercury burden are: Mercury in vaccines (e.g. DTP (at typically 25 micrograms of mercury per dose), Tetanus, Hepatitis B & (most) influenza vaccines), contamination of fish[230], wild/bush fires; and emissions from power stations[231] and industrial chimneys including incinerators, waste-burning cement works, crematoria, etc. The characteristics of autism and mercury poisoning are extremely similar which suggests that autism arises from mercury poisoning[232,233]. Children with autism have greater amounts of mercury and other heavy metals in their system[234]. For these children the exposure route is considered to be predominately via childhood vaccines, most of which contain thimerosal. Vaccinated children of circa 10-20 kgs are exposed to an adult overdose of mercury, over 62.5 micrograms of mercury within the first three months, which significantly increases a child’s risk of developing some form of neuro-developmental disorder such as impaired development, speech and language, autism, stuttering and attention deficit disorder.

Children living downstream of coal-fired power stations have a greater incidence of autistic spectrum disorders[231]. This indicates that the innate physiological processes, which the body uses to eliminate heavy metals, are being overcome by overexposure.

Mercury poisoning is an insidious process. In general the symptoms do not appear immediately upon exposure, although they may in especially sensitive individuals or in cases of excessive exposure. The initial preclinical stage is followed by the development of symptoms of mercury poisoning over a period which may last from weeks, months, and years[235–237]. Consequently, mercury given in vaccines to very young children would not be expected to lead to a recognizable disorder, except for subtle signs, before age 6-12 months, and might not emerge for several years[233].

In autistic children, the initial signs occur shortly after the first injections, and consist of abnormalities in motor behavior and in the sensory systems, particularly touch sensitivity, vision, and numbness in the mouth[15,238]. These signs are followed by parental reports of speech and hearing abnormalities appearing before the child’s second birthday[10]. Finally, there is the development of autistic-like traits and a continuing regression or lack of development in subsequent years. These symptoms change[239] depending upon the circumstances surrounding each child.

Most autistic children have impaired liver detoxification. Many have low levels of metallothionine, conceivably the consequence of a deficiency of Zinc, which is indicative of a lowered capacity to chelate mercury and other heavy metals. Mercury is a powerful oxidant which depletes cellular antioxidants, especially glutathione. The P450 detoxifying enzymes of the liver rely heavily on adequate availability of glutathione. EthylMercury the active component in thimerosal causes apoptosis of the t-cells[240–242].

Although the withdrawal of mercury from vaccines has not resulted in an overall decline in the occurrence of autism this does not mean that the problem does not lie with thimerosal[243,263]. It may indicate that the problem is associated with the elimination of mercury[244] i.e. affecting function of the lymphatic system and excretion[245]. This is supported by noting evidence of urea cycle dysfunction. Problems with the urea cycle, conceivably the consequence of mercury poisoning, have been linked to autism. A child with ornithine transcarbamylase (OTC) deficiency is likely to be lacking in energy, have appetite problems, poorly-controlled breathing rate and/or body temperature, and slow development. Significantly, OTC deficiency is an X-linked recessive disorder (http://www.merck.com/mmpe/sec13/ch164/ch164a.html) one of a number of primary immunodeficiencies associated with vaccine use.

As in autism, onset of Hg toxicity symptoms is gradual in some cases, sudden in others[232,233]. In the case of poisoning, the first signs to emerge are abnormal sensation and motor disturbances. As exposure increases, these signs are followed by speech problems, and hearing deficits[246]. Upon removal of the mercury the symptoms tend to recede except in instances of severe poisoning, which may lead to death[232]. As in autism, epilepsy arising from Hg exposure is also associated with a poor prognosis[247]. Mercury acts upon the catecholamines and influences the function of the autonomic nervous system[245]. This affects cognitive performance[248], spatial vision[249], etc.

Other metals have been implicated in adverse neurodevelopmental outcomes in children e.g. lead and mercury[250,251], with exposure to cadmium, arsenic, antimony and chromium also a concern. Studies have found adverse effects of prenatal lead exposure on growth and development, but little research has examined an association with autism. Whilst Mercury is of concern, because of evidence for neurotoxic effects and the fact that it has become so prevalent in the wider environment[250], Aluminum also shares common mechanisms with mercury e.g. it interferes with cellular and metabolic processes in the nervous system. Children given the recommended vaccinations are injected with nearly 5 mg of aluminum by the time they are just 1.5 years old, almost 6 times the safe level. Furthermore the nature of the Aluminium affects the prevailing blood levels and is also increasingly implicated, through their use as vaccine adjuvants, in autism[252]…

📍Discussion:

The mass of scientific evidence compiled by researchers clearly indicates that the incidence of autism occurs following vaccination and is most closely associated with the schedule of vaccines culminating in the MMR vaccine. That vaccines suppress natural immune function is not in dispute e.g. those with naturally low levels of immune function (immigrants from tropical climates) show greater predisposition to autistic spectrum disorders.

The immediate effect arising from vaccination influences gene function and protein expression. This leads to lower levels of white blood cells including e.g. lymphocytes, immunoglobulins, t-cells, b-cells and/or neutrophils, and disturbs their synergistic action and hence their ability to memorize and respond to immune responses when challenged. This impairs the ability to kill pathogens thereby predisposing to further infections. The short and long-term outcome is to the neural mechanisms regulating system function affecting e.g. pH, the excretory system, temperature, and the elimination of toxins and heavy metals. This explains why the discontinuation of thimerosal in vaccines was followed by a steady increase in the incidence of autism and hence that researchers did not find a correlation between the incidence of autism and the use of thimerosal-containing vaccines[263]. This may also explain the effect of multiple vaccines, in particular the MMR vaccine, and the greater predisposition to autistic spectrum disorders in military families.

In most autistic children brain structures are initially unaffected but become steadily underdeveloped as a consequence of exposure to mercury and other heavy metals. This evolves into a neurodevelopmental problem leading to chromosomal abnormalities, affecting myelination, the subsequent degeneration of the cerebellum, etc.

The MMR triple vaccine may inhibit normal immune function which, directly or indirectly, ultimately leads to chromosomal and/or genetic damage and/or dysfunction. The occurrence of GWS in adults, a condition with many features which are common with autism, indicates the problem may be due to the number and/or intense schedule of vaccinations however this does not excuse the measles or MMR vaccine from suspicion. The combined vaccine raises body temperature whilst lowering immune and system function. This may make a mild measles vaccine more virulent which may increase fever to an abnormally high level. It suggests (1) single vaccines may pose less risk than triple vaccines; (2) some vaccines pose a greater risk than others e.g. pertussis and measles; and (3) the way in which vaccines are administered will be accompanied by different side-effects e.g. if pertussis is followed by measles or vice-versa, if BCG gives a beneficial effect to be followed by pertussis, if vaccines are given in combination, etc. Increased disease loading is the inevitable consequence of multiple vaccine or lots of single vaccines or triple vaccines e.g. of asthma, autoimmune disease, etc. It suggests that adherence to the vaccine schedule is the problem – too many vaccines, too quickly.

Vaccines cause an inflammatory response in some e.g. for those with an inadequately developed or artificially lowered immune system, for those genetically predisposed, or perhaps due to viral or bacterial infection. This creates genetic damage and/or dysfunction and hence influences the brain’s ability to regulate the physiological systems, and especially to the lymphatic system and its ability to excrete mercury and heavy metals, would lead to long-term damage and problems processing sensory/cognitive input. This would inevitably affect the brain’s ability to maintain a regulated temperature below that which affects brain damage (41° C). This inevitably influences the autonomic nervous system and the stability of all related physiological systems including temperature, blood pressure, blood cell content, blood glucose, digestion, excretion, sleeping, etc.

Further evidence of multi-level dysfunction is evident from unusual brain-wave stability, aberrant sleep patterns, loss of sense perception and coordination, mirror neuron dysfunction, lower pain thresholds, mental and physical deterioration, short periods of concentration, etc. That it is a problem of systemic dysfunction is further supported by noting how it can be treated using sensory therapies which may facilitate the re-establishment of some degree of physiological stability.

Where is the proof that vaccines are safe? The argument has never been that they are completely safe but that the consequences are less than having the disease. Now it is illustrated that the consequences of intensive vaccination schedules pose a greater risk than could ever have been imagined. This leads to the evolution of new viral strains, an unsurprising development when the environment to which it is exposed is being altered by new proteins, structural variants and altered DNA.

Vaccines are an essential component of preventative healthcare however it may be necessary to review the ways in which vaccines are used, administered and regulated[141,264] i.e.

📍📍

As drugs are tested in the clinical environment to assess their interaction with other drugs, the cumulative use of vaccines including that of multiple vaccines should be researched and shown, through double-blind placebo controlled clinical trials, to be free from any such interactions i.e. of one single vaccine with another single or multiple vaccine or drug. It has been considered unethical to select a control group of children which would otherwise not be vaccinated yet such is the levels of conscientious objectors in the industrialized world and through circumstances of impoverishment in the underdeveloped countries that such statistics must currently exist.

📍📍

Measures to assess the suitability of children for vaccination i.e. how to assess whether a child has a greater predisposition to an adverse vaccine reaction and the subsequent development of autism?[265]

📍📍

The time when vaccinations should be given and the time between vaccinations e.g. giving mumps and rubella vaccinations later in childhood.

📍📍

Are some vaccines necessary in the industrialized world e.g. mumps, rubella, Hib, Hpv, etc? With more than 200 other vaccines under development this must be an issue of review.

The risks from disease and vaccinations differ upon location. In the developed world, there is an estimated 0.1-0.3% risk of mortality from measles which compares with a 0.6% risk and rising (with some estimates at 1-2%) of autism. This excludes the cost of treating the wide range of side-effects which must clearly be attributed to the use of vaccines. The cost of treating vaccine-related side-effects may now be far greater than the diseases against which the vaccine(s) were designed to protect. Furthermore, in the developed world there is a highly developed social structure which is able to assist parents to deal with the condition. By comparison, what are the implications for an autistic child in the developing world where there is absence of resources to deal with the condition?

📍For more information, please see:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364648/

One thought on “~Regressive Autism – North American Journal of Medical Sciences~

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