Phytocannabinoids in the Treatments of Cancer – US 20130059018 A1

📍ABSTRACT:

This invention relates to the use of phytocannabinoids, either in an isolated form or in the form of a botanical drug substance (BDS) in the treatment of cancer. Preferably the cancer to be treated is cancer of the prostate, cancer of the breast or cancer of the colon.

📍CLAIMS:

1. A method of treating a patient comprising administering a therapeutically effective amount of a cannabis plant extract comprising a phytocannabinoid containing component and a non-phytocannabinoid containing component, wherein the phytocannabinoid containing component comprises at least 50% (w/w) of the cannabis plant extract and in which the principle is not tetrahydrocannabinol (THC) or cannabidiol (CBD), and the non-phytocannabinoid containing component comprises at least 15% (w/w) of the cannabis plant extract and further comprises a monoterpene fraction comprising a principle monoterpene which is selected from myrcenes or pinenes and a sesquiterpene fraction comprising a principle sesquiterpene which is selected from caryophyllenes or humulenes to the patient.

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Considering that up until about 85 years ago, cannabis oil was used around the world to treat a variety of diseases, including cancer, it is not surprising that the phasing out of cannabis to treat illness coincided with the rise of pharmaceutical companies.

Rick Simpson, a medical marijuana activist, is on a crusade to help others heal. He regards cannabis as the most medicinally active plant on the face of the earth, and shared this apparent miracle with others — completely free of charge. He now has thousands of testimonials from those who were healed from ‘incurable’ disease to back up his claims ~ that cannabis annihilates cancer.

For the cynics out there who are still not convinced about the effectiveness of cannabis for curing cancer, the astounding healing attributes of the plant are well documented by a wealth of peer-reviewed studies.

Traditional medicinal plant backed by modern medicine:

📍Breast Cancer:

A study in Molecular Cancer Therapeutics explored the relationship between the use of cannabidiol (CBD) and the subsequent down regulation of breast cancer tumour aggressiveness. The researchers concluded that CBD represents the first nontoxic agent to decrease the aggressiveness of metastic breast cancer cells in vivo.

Several additional studies support these findings, including “Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion and metastasis” and “Cannabinoids: a new hope for breast cancer therapy?”

Furthermore, the journal PLoS One reports further evidence of how cannabinoids modulate breast cancer tumour growth and metastasis by inhibiting specific receptors.

📍Colon Cancer:

As published in Pharmacological Research: “Studies on epithelial cells have shown that cannabinoids exert antiproliferative, antimetastatic and apoptotic effects as well as reducing cytokine release and promoting wound healing. In vivo, cannabinoids – via direct or indirect activation of CB(1) and/or CB(2) receptors – exert protective effects in well-established models of intestinal inflammation and colon cancer.” The team concluded that the administration of cannabinoids “may be a promising strategy to counteract intestinal inflammation and colon cancer.”

Moreover, research in the Scandinavian Journal of Gastroenterology established that colon cancer cell lines were strongly affected by cannabinoids.

📍Leukaemia:

Cannabis was shown to induce cytotoxicity in leukaemia cell lines, according the the journal Blood: “We have shown that THC is a potent inducer of apoptosis, even at 1 x IC(50) (inhibitory concentration 50%) concentrations and as early as 6 hours after exposure to the drug. These effects were seen in leukaemic cell lines (CEM, HEL-92, and HL60) as well as in peripheral blood mononuclear cells.”

It also did not appear that the cannabis was simply aiding other chemo drugs — it was independently bringing about results with the active compound THC responsible for cancer cell death in vitro.

Likewise, a study in the Molecular Pharmacology Journal found that non psychoactive cannabidiol dramatically induced apoptosis (cell death) in leukaemia cells. “Together, the results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22(phox) expression, may be a novel and highly selective treatment for leukaemia.”

Two additional studies, “p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells” and “Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukaemia cells“, also demonstrated the effectiveness of cannabis in promoting leukaemia cell death.

📍Immunity:

Research published in the paper Prostaglandins, Leukotrienes and Essential Fatty Acids found that cannabinoid compounds play a vital role in modulating the immune system to improve the outcome of a cancer diagnosis. In short, the team believes “The experimental evidence reviewed in this article argues in favor of the therapeutic potential of these compounds in immune disorders and cancer.”

Moreover, the study Cannabinoids and the Immune System confirms that cannabimimetic agents have substantial effects on natural killer cells, thereby providing therapeutic usefulness in reducing tumour growth and the induction of apoptosis. Therefore, cannabis demonstrates a “subtle but significant role in the regulation of immunity and that this role can eventually be exploited in the management of human disease.”

📍Cervical Cancer:

Uterine cervical cancer cells are significantly influenced by cannabis as well. Published in Gynaecologic Oncology, the research team discovered that the compound induced apoptosis in cervical carcinoma (CxCa) cell lines.

📍Melanoma:

The most deadly form of skin cancer, melanoma has relatively few options of treatment beyond prevention and early detection. With this in mind, the findings of the study Cannabinoid Receptors As Novel Targets for the Treatment of Melanoma are of particular note. In animal tests, cannabinoids encouraged cancer cell death, while decreasing growth, proliferation and metastasis of melanoma cells.

Non-melanoma skin cancers also respond well to cannabinoids. According to research in the Journal of Clinical Investigation: “Local administration of [cannabinoids] induced a considerable growth-inhibition of malignant tumours generated by inoculation of epidermal tumour cells into nude mice. Cannabinoid-treated tumours showed an increased number of apoptotic cells. This was accompanied by impairment of tumour vascularisation, as determined by altered blood vessel morphology and decreased expression of proangiogenic factors (VEGF, placental growth factor, and angiopoietin 2). … These results support a new therapeutic approach for the treatment of skin tumours.”

These are just a few examples — among hundreds — that demonstrate the effectiveness of cannabis in eradicating cancer without adverse side-effects. Additionally, the following documentary explores the history and modern uses of cannabis to heal serious diseases such as cancer, AIDS, Crohn’s disease & more:

Medical Cannabis and Its Impact on Human Health: a Cannabis Documentary

📍https://m.youtube.com/watch?v=VsDic2na8co

~~✖️✖️- Scientific Studies from the National Institute of Health -✖️✖️~~

If you’re still in doubt regarding the effectiveness of cannabis for healing cancer, have a look at these 100+ scientific studies from the National Institute of Health:

📍Cannabis Kills Tumour Cells:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576089

http://www.ncbi.nlm.nih.gov/pubmed/20090845

http://www.ncbi.nlm.nih.gov/pubmed/616322

http://www.ncbi.nlm.nih.gov/pubmed/14640910

http://www.ncbi.nlm.nih.gov/pubmed/19480992

http://www.ncbi.nlm.nih.gov/pubmed/15275820

http://www.ncbi.nlm.nih.gov/pubmed/15638794

http://www.ncbi.nlm.nih.gov/pubmed/16818650

http://www.ncbi.nlm.nih.gov/pubmed/17952650

http://www.ncbi.nlm.nih.gov/pubmed/20307616

http://www.ncbi.nlm.nih.gov/pubmed/16616335

http://www.ncbi.nlm.nih.gov/pubmed/16624285

http://www.ncbi.nlm.nih.gov/pubmed/10700234

http://www.ncbi.nlm.nih.gov/pubmed/17675107

http://www.ncbi.nlm.nih.gov/pubmed/14617682

http://www.ncbi.nlm.nih.gov/pubmed/17342320

http://www.ncbi.nlm.nih.gov/pubmed/16893424

http://www.ncbi.nlm.nih.gov/pubmed/15026328

📍Uterine, Testicular and Pancreatic Cancers:

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4

http://www.ncbi.nlm.nih.gov/pubmed/20925645

📍Brain Cancer:

http://www.ncbi.nlm.nih.gov/pubmed/11479216

📍Mouth and Throat Cancer:

http://www.ncbi.nlm.nih.gov/pubmed/20516734

📍Breast Cancer:

http://www.ncbi.nlm.nih.gov/pubmed/18454173

http://www.ncbi.nlm.nih.gov/pubmed/16728591

http://www.ncbi.nlm.nih.gov/pubmed/965319

📍Lung Cancer:

http://www.ncbi.nlm.nih.gov/pubmed/25069049

http://www.ncbi.nlm.nih.gov/pubmed/22198381?dopt=Abstract

http://www.ncbi.nlm.nih.gov/pubmed/21097714?dopt=Abstract

📍Prostate Cancer:

http://www.ncbi.nlm.nih.gov/pubmed/12746841?dopt=Abstract

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?tool=pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22594963

http://www.ncbi.nlm.nih.gov/pubmed/15753356

http://www.ncbi.nlm.nih.gov/pubmed/10570948

http://www.ncbi.nlm.nih.gov/pubmed/19690545

📍Blood Cancer:

http://www.ncbi.nlm.nih.gov/pubmed/12091357

http://www.ncbi.nlm.nih.gov/pubmed/16908594

📍Skin Cancer:

http://www.ncbi.nlm.nih.gov/pubmed/12511587

http://www.ncbi.nlm.nih.gov/pubmed/19608284

📍Liver Cancer:

http://www.ncbi.nlm.nih.gov/pubmed/21475304

📍Cannabis Cancer Cures (general):

http://www.ncbi.nlm.nih.gov/pubmed/12514108

http://www.ncbi.nlm.nih.gov/pubmed/15313899

http://www.ncbi.nlm.nih.gov/pubmed/20053780

http://www.ncbi.nlm.nih.gov/pubmed/18199524

http://www.ncbi.nlm.nih.gov/pubmed/19589225

http://www.ncbi.nlm.nih.gov/pubmed/12182964

http://www.ncbi.nlm.nih.gov/pubmed/19442435

http://www.ncbi.nlm.nih.gov/pubmed/12723496

http://www.ncbi.nlm.nih.gov/pubmed/16250836

http://www.ncbi.nlm.nih.gov/pubmed/17237277

📍Cancers of the Head and Neck:

http://ww.ncbi.nlm.nih.gov/pmc/articles/PMC2277494

📍Cholangiocarcinoma Cancer:

http://ww.ncbi.nlm.nih.gov/pubmed/19916793

http://www.ncbi.nlm.nih.gov/pubmed/21115947

📍Leukaemia:

http://www.ncbi.nlm.nih.gov/pubmed/15454482

http://www.ncbi.nlm.nih.gov/pubmed/16139274

http://www.ncbi.nlm.nih.gov/pubmed/14692532

📍Cannabis Partially/Fully-Induced Cancer Cell Death:

http://www.ncbi.nlm.nih.gov/pubmed/12130702

http://www.ncbi.nlm.nih.gov/pubmed/19457575

http://www.ncbi.nlm.nih.gov/pubmed/18615640

http://www.ncbi.nlm.nih.gov/pubmed/17931597

http://www.ncbi.nlm.nih.gov/pubmed/18438336

http://www.ncbi.nlm.nih.gov/pubmed/19916793

http://www.ncbi.nlm.nih.gov/pubmed/18387516

http://www.ncbi.nlm.nih.gov/pubmed/15453094

http://www.ncbi.nlm.nih.gov/pubmed/19229996

http://www.ncbi.nlm.nih.gov/pubmed/9771884

http://www.ncbi.nlm.nih.gov/pubmed/18339876

http://www.ncbi.nlm.nih.gov/pubmed/12133838

http://www.ncbi.nlm.nih.gov/pubmed/16596790

http://www.ncbi.nlm.nih.gov/pubmed/11269508

http://www.ncbi.nlm.nih.gov/pubmed/15958274

http://www.ncbi.nlm.nih.gov/pubmed/19425170

http://www.ncbi.nlm.nih.gov/pubmed/17202146

http://www.ncbi.nlm.nih.gov/pubmed/11903061

http://www.ncbi.nlm.nih.gov/pubmed/15451022

http://www.ncbi.nlm.nih.gov/pubmed/20336665

http://www.ncbi.nlm.nih.gov/pubmed/19394652

http://www.ncbi.nlm.nih.gov/pubmed/11106791

http://www.ncbi.nlm.nih.gov/pubmed/19189659

http://www.ncbi.nlm.nih.gov/pubmed/16500647

http://www.ncbi.nlm.nih.gov/pubmed/19539619

http://www.ncbi.nlm.nih.gov/pubmed/19059457

http://www.ncbi.nlm.nih.gov/pubmed/16909207

http://www.ncbi.nlm.nih.gov/pubmed/18088200

http://www.ncbi.nlm.nih.gov/pubmed/10913156

http://www.ncbi.nlm.nih.gov/pubmed/18354058

http://www.ncbi.nlm.nih.gov/pubmed/19189054

http://www.ncbi.nlm.nih.gov/pubmed/17934890

http://www.ncbi.nlm.nih.gov/pubmed/16571653

http://www.ncbi.nlm.nih.gov/pubmed/19889794

http://www.ncbi.nlm.nih.gov/pubmed/15361550

📍Translocation-Positive Rhabdomyosarcoma:

http://www.ncbi.nlm.nih.gov/pubmed/19509271

📍Lymphoma:

http://www.ncbi.nlm.nih.gov/pubmed/18546271

http://www.ncbi.nlm.nih.gov/pubmed/16936228

http://www.ncbi.nlm.nih.gov/pubmed/16337199

http://www.ncbi.nlm.nih.gov/pubmed/1960900

📍Cannabis Kills Cancer Cells:

http://www.ncbi.nlm.nih.gov/pubmed/16818634

http://www.ncbi.nlm.nih.gov/pubmed/12648025

http://www.ncbi.nlm.nih.gov/pubmed/17952650

http://www.ncbi.nlm.nih.gov/pubmed/16835997

📍Melanoma:

http://www.ncbi.nlm.nih.gov/pubmed/17065222

📍Thyroid Carcinoma:

http://www.ncbi.nlm.nih.gov/pubmed/18197164

📍Colon Cancer:

http://www.ncbi.nlm.nih.gov/pubmed/18938775

http://www.ncbi.nlm.nih.gov/pubmed/19047095

📍Intestinal Inflammation and Cancer:

http://www.ncbi.nlm.nih.gov/pubmed/19442536

📍Cannabinoids in Health and Disease:

http://www.ncbi.nlm.nih.gov/pubmed/18286801

📍Cannabis Inhibits Cancer Cell Invasion:

http://www.ncbi.nlm.nih.gov/pubmed/19914218

~~✖️✖️- FACEBOOK -✖️✖️~~

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